HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 6-bromo-7-hydroxy-3,4,4a,8a-tetrahydro-1H-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | HCID 67152391 | HCID 67152391 | — |
| Product | 6-bromo-7-hydroxy-3,4,4a,8a-tetrahydro-1H-quinolin-2-one | HCID 66911311 | — |
Reaction Steps
This intermediate was obtained according to general procedure I from 7-hydroxy-3,4,4a,8a-tetrahydro-1H-quinolin-2-one (370 mg, 2.27 mmol) and NBS (424 mg, 2.38 mmol) after flash chromatography on silica gel (hexanes/ethyl acetate, 1/1, Rf=0.15) as white solid (500 mg, 2.07 mmol, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541404B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-8ec8940afebb474fb983513d139ac7bc |
| Source note | uspto-grants-2013_09 |