2-Bromo-2-methylpropanoic acid → HCID 21418530, compound

HRID 441846Notes

Reaction equation

HRID 441846 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:26][CH3:27])=[C:6]([CH:25]=1)[C:7]([NH:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=2)=[CH:14][CH:13]=1)=[O:8].Br[C:29]([CH3:34])([CH3:33])[C:30]([OH:32])=[O:31]>>[CH3:33][C:29]([O:24][C:21]1[CH:22]=[CH:23][C:18]([C:15]2[CH:16]=[CH:17][C:12]([CH2:11][CH2:10][NH:9][C:7](=[O:8])[C:6]3[CH:25]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=3[O:26][CH3:27])=[CH:13][CH:14]=2)=[CH:19][CH:20]=1)([CH3:34])[C:30]([OH:32])=[O:31]

Participants

3

Reactant 2

HCID 749242-Bromo-2-methylpropanoic acidHCID 21418526HCID 21418526, compound

Product 1

HCID 21418530HCID 21418530, compound

Procedure

2-Methyl-2-{4-[2-(5-chloro-2-methoxy-benzamido)-ethyl]-biphenyl-4'-oxy}-propionic acid was prepared from 4-[2-(5-chloro-2-methoxy-benzamido)-ethyl]-4'-hydroxy-biphenyl and 2-bromo-2-methyl-propionic acid analogous to Example 11. M.p. 145° C. M + H = 468; Mcalc = 467.96.

Sources & evidence

ORD record
ord-dc00fcf71822463eb190e686cfa7c1c0
Source dataset
uspto-grants-1977_08
Patent number
US04042711

Reaction notes

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