反应详情

2.2 g. of [4-phenyl-1-(4-tolyl)-3-pyrazolyl]-acetyl chloride crude product are reacted with 5 ml. of absolute benzene and 5 ml. of absolute ethanol. 0.2 ml. of pyridine are added dropwise to this mixture, which is allowed to stand at room temperature for 16 hours, and then diluted with 20 ml. of benzene. The reaction mixture then is washed in turn with water, diluted hydrochloric acid and water; dried and concentrated in vacuum. The residue is recrystallized from acetone/hexane. 1.7 g. of [4-phenyl-1-(4-tolyl)-3-pyrazolyl]-acetic acid ethyl ester with a melting point of 76°-79° C., is obtained.

1. additiondiluted with 20 ml
2. washThe reaction mixture then is washed in turn with water, diluted hydrochloric acid and water
3. customdried
4. concentrationconcentrated in vacuum
5. customThe residue is recrystallized from acetone/hexane