HCID 13069709, compound → HCID 13069710, compound

HRID 441851Notes

Reaction equation

HRID 441851 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:11]([CH2:21][C:22]([OH:24])=[O:23])=[N:12][N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:14]=2)=[CH:6][CH:5]=1)([O-])=O>[Ni].COCCO>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[C:11]([CH2:21][C:22]([OH:24])=[O:23])=[N:12][N:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:14]=2)=[CH:8][CH:9]=1

Participants

4

Reactant 1

HCID 13069709HCID 13069709, compound

Product 1

HCID 13069710HCID 13069710, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 80192-MethoxyethanolSolvent

Procedure

210 mg. of [4-(4-nitrophenyl)-1-phenyl-3-pyrazolyl]acetic acid are reacted with 20 ml. of glycol monomethyl ether and 1 g. of Raney nickel and hydrogenated at room temperature under normal pressure. The reaction is worked up as described in Example 17(c). [4-(4-Aminophenyl)-1-phenyl-3-pyrazolyl]acetic acid is obtained.

Workup

  1. customhydrogenated at room temperature

Sources & evidence

ORD record
ord-ba067a510e4d4ba983f986b875e816de
Source dataset
uspto-grants-1977_08
Patent number
US04042706

Reaction notes

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