Sulfuric Acid → HCID 21418271, compound

HRID 441855Notes

Reaction equation

[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[CH2:20][C:21](N)=[O:22].S(=O)(=O)(O)[OH:25]>>[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[CH2:20][C:21]([OH:22])=[O:25]

Participants

Reactant 2

HCID 1118Sulfuric Acid

HCID 53741545HCID 53741545, compound

Product 1

HCID 21418271HCID 21418271, compound

Procedure

2.0 g of 5-chloro-3-p-chlorophenyl-1-phenyl-pyrazole-4-acetamide and 10 g of 63 % sulfuric acid are heated for 1.5 hours at 100° C. and prepared in accordance with example 2. 5-Chloro-3-p-chlorophenyl-1-phenyl-pyrazole-4-acetic acid is obtained: F 179.5°-181°.

Workup

customprepared in accordance with example 2

Sources & evidence

ORD record: ord-5eaab522c73b48b7b8aaf4a8fbabd196
Source dataset: uspto-grants-1977_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04042702

Reaction notes

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