Ethanol → HCID 53996186, compound

HRID 441866Notes

Reaction equation

HRID 441866 reaction equation
[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[CH2:20][C:21]([OH:23])=[O:22].[CH2:24](O)[CH3:25].S(=O)(=O)(O)O>O>[Cl:1][C:2]1[N:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]

Participants

5

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 21418271HCID 21418271, compound

Product 1

HCID 53996186HCID 53996186, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

6.9 g of 5-chloro-3-p-chlorophenyl-1-phenyl-pyrazole-4-acetic acid, 70 ml of ethanol and 4 g of concentrated sulfuric acid are heated at boiling for 8 hours. The liquid is reduced in volume, poured into water and ice, extracted with ether, washed with sodium carbonate solution, the organic solution is dried and reduced in volume. Ethyl 5-chloro-3-p-chlorophenyl-1-phenyl-pyrazole-4-acetate is obtained with a yield of 85 %; F 51.5°-52.5°.

Workup

  1. extractionextracted with ether
  2. washwashed with sodium carbonate solution
  3. customthe organic solution is dried

Sources & evidence

ORD record
ord-22408fa9501d4cdf9ddf688bc00fbec6
Source dataset
uspto-grants-1977_08
Patent number
US04042702

Reaction notes

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