Sulfuric Acid → HCID 53741545, compound

HRID 441867Notes

Reaction equation

HRID 441867 reaction equation
[Cl:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[CH2:20][C:21]#[N:22].S(=O)(=O)(O)[OH:24]>>[Cl:1][C:2]1[N:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=2)[C:3]=1[CH2:20][C:21]([NH2:22])=[O:24]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 53778394HCID 53778394, compound

Product 1

HCID 53741545HCID 53741545, compoundYield 99%

Procedure

5g of 5-chloro-3-p-chlorophenyl-1-phenyl-pyrazole-4-acetonitrile and 10 ml of 96 % sulfuric acid are stirred for 4 hours at room temperature. The batch is added to 50 g of ice, the precipitate is separated by vacuum filtering and washed with water. 5-Chloro-3-p-chlorophenyl-1-phenyl-pyrazole-4-acetamide is obtained with a 99 % yield; F 192°-193°.

Workup

  1. customthe precipitate is separated by vacuum
  2. filtrationfiltering
  3. washwashed with water

Sources & evidence

ORD record
ord-6857f371b1034a64a0c2e11d1beda282
Source dataset
uspto-grants-1977_08
Patent number
US04042702

Reaction notes

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