Dicyclohexylcarbodiimide → HCID 21418112, compound

HRID 441883Notes

Reaction equation

HRID 441883 reaction equation
[CH2:1]([N:8]1[CH2:13][C:12]2[C:14]3[C:23]([OH:24])=[CH:22][C:21]([CH:25]([CH:27]([CH3:33])[CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[CH3:26])=[CH:20][C:15]=3[O:16][C:17]([CH3:19])([CH3:18])[C:11]=2[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:34].[O:35]1[CH2:40][CH2:39][N:38]([CH2:41][CH2:42][CH2:43][C:44](O)=[O:45])[CH2:37][CH2:36]1.C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[ClH:34].[CH2:1]([N:8]1[CH2:13][C:12]2[C:14]3[C:23]([O:24][C:44](=[O:45])[CH2:43][CH2:42][CH2:41][N:38]4[CH2:37][CH2:36][O:35][CH2:40][CH2:39]4)=[CH:22][C:21]([CH:25]([CH:27]([CH3:33])[CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[CH3:26])=[CH:20][C:15]=3[O:16][C:17]([CH3:19])([CH3:18])[C:11]=2[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 10765851HCID 10765851, compoundHCID 127337464-Morpholin-4-Yl-Butyric Acid Hydrochloride

Product 1

HCID 21418112HCID 21418112, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Benzyl-5,5-dimethyl-10-hydroxy-8-(3-methyl-2-octyl)-1,2,3,4-tetrahydro-5H-[1]benzopyrano[3,4-d]pyridine, γ-morpholinobutyric acid hydrochloride and dicyclohexyl-carbodiimide are combined in equimolar amounts in methylene chloride and reacted as in Example 1 to give the desired product.

Workup

  1. customreacted as in Example 1

Sources & evidence

ORD record
ord-af86e33926c2437ebee4c48c15127434
Source dataset
uspto-grants-1977_08
Patent number
US04042694

Reaction notes

Loading…