HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylhydrazine → 5-Cyclohexyl-2-methyl-2,4-dihydro-3H-pyrazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | Ethyl 3-cyclohexyl-3-oxopropanoate | HCID 266327 | — |
| Solvent | 1-Propanol | HCID 1031 | — |
| Product | 5-Cyclohexyl-2-methyl-2,4-dihydro-3H-pyrazol-3-one | HCID 15203938 | — |
Reaction Steps
To ethyl β-oxocyclohexanepropionate (4.4 g, 0.234 mole) in n-propanol (500 ml) is added dropwise with stirring under nitrogen at 80° C. methylhydrazine (13.8 g, 0.3 mole). After heating at reflux during 5 hours, the reaction is cooled and evaporated to a residual oil. Crystallization from ethylacetate gives a white powder mp 170.5° to 172° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04044013 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-0e520f958fcb4f41ad2ff2276cd2a0e5 |
| Source note | uspto-grants-1977_08 |