HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 8-Fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]-thiepin-10-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 8-fluoro-2-methyl-dibenzo[b,f]thiepin-10(11H)-one | HCID 12275541 | — |
| Solvent | Water | HCID 962 | — |
| Product | 8-Fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]-thiepin-10-ol | HCID 12275542 | — |
Reaction Steps
103 G. of 8-fluoro-2-methyl-dibenzo[b,f]-thiepin-10(11H)-one is suspended in 550 ml. of ethanol and mixed with 24.3 g. of sodium borohydride. The reaction mixture is heated for about 10 minutes under reflux conditions. The reaction mixture, after the addition of water, is extracted with chloroform. The organic phase is again washed with water, dried over sodium sulfate and evaporated, whereby there is obtained 8-fluoro-10,11-dihydro-2-methyl-dibenzo[b,f]-thiepin-10-ol as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04044010 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-040311cdda7249b697f8c6b739b90347 |
| Source note | uspto-grants-1977_08 |