Hydrogen Bromide → HCID 22795868, compound

Participants

Reaction Steps

0.40 g of 5-chloro-2'-fluoro-2-{5-[(N-benzyloxycarbonyl-L-leucyl)aminomethyl]-1-imidazolyl}benzophenone was treated with a 35% solution of hydrogen bromide in glacial acetic acid for 45 minutes. Dry diethyl ether was then added, an oily solid being obtained. The product was precipitated from methanol/ethyl acetate, dissolved in water and freeze-dried. There was obtained 5-chloro-2'-fluoro-2-[5-(L-leucylaminomethyl)-2-methyl-1-imidazolyl]benzophenone dihydrobromide in a yield of 0.25 g (60%); [α]D20 = -5.5° (c = 0.2708 in water).

Provenance & Evidence