Benzene → HCID 13243693, compound

Participants

Reaction Steps

A mixture of a solution of 0.94 g of the thus obtained di-(chloroacetyl) derivative of 3-amino-6-bromo-4-hydroxy-4-(2-pyridyl)-3,4-dihydroquinazoline in 19 ml. of benzene and 0.4 g of monochloroacetic acid is refluxed for 30 minutes. Then, the resulting benzene layer is washed with water and separated from the mixture. After evaporation of benzene under reduced pressure, the residue is washed with a mixture of methanol and isopropyl ether to give 4-[4-bromo-2-(2-pyridinecarbonyl)phenyl]-3-chloromethyl-4H-1,2,4-triazole as crystals. Recrystallization from ethyl acetate gives colorless crystals, melting at 146° to 147° C.

Provenance & Evidence