Ethanol → HCID 178481740, compound

Participants

Reaction Steps

A mixture of 14.4 grams of 4-cyano-5-ethoxymethylene amino-1-methyl-3-(5-nitro-2-furyl)-pyrazole, 3.5 grams of hydroxylamine hydrochloride, 150 millilitres of ethanol and a solution containing 2.0 grams of sodium hydroxide dissolved in 10 millitres of water was heated at reflux for 1 hour and cooled. The crystalline product was filtered, washed with ethanol and dried. Recrystallisation from water gave 4-amino-1-methyl-3-(5-nitro-2-furyl)-1H-pyrazolo [3,4-d] pyrimidin-5-oxide having melting point 285° C; melting point, infra-red and proton NMR spectra being identical with the product obtained in Example 20.

Provenance & Evidence