HCID 68122223, compound → HCID 13673470, compound

HRID 442158Notes

Reaction equation

HRID 442158 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:31]=[CH:32][C:33]=1[O:34][CH3:35])[CH2:6][O:7][C:8]([C:10]1[CH:11]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[N+:28]([O-:30])=[O:29])[C:12]([C:18]([O:20]C)=O)=C(C)[NH:14][C:15]=1[CH3:16])=[O:9]>CO>[CH3:6][O:7][C:8]([CH2:10][C:18](/[CH:12]=[CH:11]/[C:22]1[C:23]([N+:28]([O-:30])=[O:29])=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:20])=[O:9].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:31]=[CH:32][C:33]=1[O:34][CH3:35])[CH2:6][O:7][C:8](=[O:9])/[CH:10]=[C:15](\[NH2:14])/[CH3:16]

Participants

4

Reactant 1

HCID 68122223HCID 68122223, compound

Product 2

HCID 13673470HCID 13673470, compoundHCID 86735019HCID 86735019, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Analogously to Example 1 heating a solution of 65 mmols of 2'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid 3,4-dimethoxybenzyl ester in 120 ml of glycol monomethyl ester for 5 hours gave 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3,4-dimethoxybenzyl ester of melting point 149° C (from methanol).

Sources & evidence

ORD record
ord-c69cb86b260f484ab7f489ea2bb43e32
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

Loading…