HCID 68122286, compound → HCID 70595485, compound

HRID 442160Notes

Reaction equation

HRID 442160 reaction equation
[Cl:1][C:2]1[CH:32]=[CH:31][C:5]([CH2:6][O:7][C:8]([C:10]2C(C3C=CC=C([N+]([O-])=O)C=3)C(C(OC)=O)=C(C)[NH:14][C:15]=2[CH3:16])=[O:9])=[CH:4][CH:3]=1>C(O)C>[Cl:1][C:2]1[CH:32]=[CH:31][C:5]([CH2:6][O:7][C:8](=[O:9])/[CH:10]=[C:15](\[NH2:14])/[CH3:16])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 68122286HCID 68122286, compound

Product 1

HCID 70595485HCID 70595485, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid 4-chlorobenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-methoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 4-chlorobenzyl ester of melting point 169° C (from ethanol).

Sources & evidence

ORD record
ord-ef9e520af5fd47e9aa4246170b1cf50f
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

Loading…