Ethanol → HCID 86735020, compound

HRID 442162Notes

Reaction equation

HRID 442162 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[CH2:5][O:6][C:7]([C:9]1C(C2C=CC=C([N+]([O-])=O)C=2)C(C(OC)=O)=C(C)[NH:13][C:14]=1[CH3:15])=[O:8].C(O)C>N1C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][CH:32]=1)[CH2:5][O:6][C:7](=[O:8])/[CH:9]=[C:14](\[NH2:13])/[CH3:15]

Participants

4

Reactant 2

HCID 702EthanolHCID 68121757HCID 68121757, compound

Product 1

HCID 86735020HCID 86735020, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid 3-chlorobenzyl ester in 120 ml of pyridine gave 2,6 dimethyl-3-methoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3-chlorobenzyl ester of melting point 142° C (from ethanol).

Sources & evidence

ORD record
ord-7b2084127df3437b869431b76ee63fce
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

Loading…