HCID 46887808, compound → HCID 86735019, compound

HRID 442165Notes

Reaction equation

HRID 442165 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:31]=[CH:32][C:33]=1[O:34][CH3:35])[CH2:6][O:7][C:8]([C:10]1C(C2C=CC=C([N+]([O-])=O)C=2)C(C(OC)=O)=C(C)[NH:14][C:15]=1[CH3:16])=[O:9]>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:31]=[CH:32][C:33]=1[O:34][CH3:35])[CH2:6][O:7][C:8](=[O:9])/[CH:10]=[C:15](\[NH2:14])/[CH3:16]

Participants

3

Reactant 1

HCID 46887808HCID 46887808, compound

Product 1

HCID 86735019HCID 86735019, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-n1trobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid 3,4-dimethoxybenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-methoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3,4-dimethoxybenzyl ester of melting point 129° C (from ethanol).

Sources & evidence

ORD record
ord-0add4589ab544cb5bf8806c1de2e747d
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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