HCID 23317513, compound → HCID 23238892, compound

HRID 442166Notes

Reaction equation

HRID 442166 reaction equation
[C:1]1([CH2:7][CH2:8][O:9][C:10]([C:12]2C(C3C=CC=C([N+]([O-])=O)C=3)C(C(OC)=O)=C(C)[NH:16][C:17]=2[CH3:18])=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C>[C:1]1([CH2:7][CH2:8][O:9][C:10](=[O:11])/[CH:12]=[C:17](\[NH2:16])/[CH3:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 1

HCID 23317513HCID 23317513, compound

Product 1

HCID 23238892HCID 23238892, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid 2-phenylethyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-methoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 2-phenylethyl ester of melting point 122° C (from ethanol).

Sources & evidence

ORD record
ord-9cd75d3fafb54371b01065e2e7637548
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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