HCID 68122435, compound → HCID 86735021, compound

HRID 442171Notes

Reaction equation

HRID 442171 reaction equation
[Cl:1][C:2]1[CH:34]=[CH:33][CH:32]=[CH:31][C:3]=1[CH2:4][O:5][C:6]([C:8]1C(C2C=CC=C([N+]([O-])=O)C=2)C(C(OC(C)C)=O)=C(C)[NH:12][C:13]=1[CH3:14])=[O:7]>C(O)C>[Cl:1][C:2]1[CH:34]=[CH:33][CH:32]=[CH:31][C:3]=1[CH2:4][O:5][C:6](=[O:7])/[CH:8]=[C:13](\[NH2:12])/[CH3:14]

Participants

3

Reactant 1

HCID 68122435HCID 68122435, compound

Product 1

HCID 86735021HCID 86735021, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid isopropyl ester and 75 mmols of β-aminocrotonic acid 2-chlorobenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-isopropoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 2-chlorobenzyl ester of melting point 103° C (from ethanol).

Sources & evidence

ORD record
ord-2a4ab4df89c14aa4a60f84062c02298a
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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