HCID 68122698, compound → HCID 70595018, compound

HRID 442172Notes

Reaction equation

HRID 442172 reaction equation
[CH3:1][C:2]1[CH:34]=[CH:33][C:5]([CH2:6][O:7][C:8]([C:10]2C(C3C=CC=C([N+]([O-])=O)C=3)C(C(OC(C)C)=O)=C(C)[NH:14][C:15]=2[CH3:16])=[O:9])=[CH:4][CH:3]=1>C(O)C>[CH3:1][C:2]1[CH:34]=[CH:33][C:5]([CH2:6][O:7][C:8](=[O:9])/[CH:10]=[C:15](\[NH2:14])/[CH3:16])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 68122698HCID 68122698, compound

Product 1

HCID 70595018HCID 70595018, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid isopropyl ester and 75 mmols of β-aminocrotonic acid 4-methylbenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-isopropoxycarbonyl-4-(3'-nitrophenyl)1,4-dihydropyridine-5-carboxylic acid 4-methylbenzyl ester of melting point 106° C (from ethanol).

Sources & evidence

ORD record
ord-3a452002766549cc86513c997d470ee2
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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