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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 442174Generated: October 29, 2026

2,6-Dimethyl-3-(2-methoxyethyloxy)-carbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid benzyl ester → (Z)-Benzyl 3-aminobut-2-enoate

https://huagongshe.com/reaction/442174

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2,6-Dimethyl-3-(2-methoxyethyloxy)-carbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid benzyl esterHCID 86735022—
SolventEthanolHCID 702—
Product(Z)-Benzyl 3-aminobut-2-enoateHCID 536834579%

Reaction Steps

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid 2-methoxyethyl ester and 75 mmols of β-aminocrotonic acid benzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-(2-methoxyethyloxy)-carbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid benzyl ester of melting point 152° C (from ethanol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04044141
Source datasetuspto-grants-1977_08
ORD IDord-93a94821e8fb4268bafd42e2670c4d67
Source noteuspto-grants-1977_08