HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Dimethyl-3-isobutoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid benzyl ester → (Z)-Benzyl 3-aminobut-2-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Dimethyl-3-isobutoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid benzyl ester | HCID 68121565 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (Z)-Benzyl 3-aminobut-2-enoate | HCID 5368345 | 71% |
Reaction Steps
Analogously to Example 1 heating a solution of 75 mmols of 2'-nitrobenzylideneacetoacetic acid isobutyl ester and 75 mmols of β-aminocrotonic acid benzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-isobutoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid benzyl ester of melting point 154° C (from ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04044141 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-bf8e58456cc14901a2fab2e70aef190b |
| Source note | uspto-grants-1977_08 |