HCID 68122166, compound → HCID 13673470, compound

HRID 442181Notes

Reaction equation

HRID 442181 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][C:32]=1[CH3:33])[CH2:5][O:6][C:7]([C:9]1[CH:10]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=2[N+:27]([O-:29])=[O:28])[C:11]([C:17]([O:19]C)=O)=C(C)[NH:13][C:14]=1[CH3:15])=[O:8]>C(O)C>[CH3:5][O:6][C:7]([CH2:9][C:17](/[CH:11]=[CH:10]/[C:21]1[C:22]([N+:27]([O-:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:19])=[O:8].[Cl:1][C:2]1[CH:3]=[C:4]([CH:30]=[CH:31][C:32]=1[CH3:33])[CH2:5][O:6][C:7](=[O:8])/[CH:9]=[C:14](\[NH2:13])/[CH3:15]

Participants

4

Reactant 1

HCID 68122166HCID 68122166, compound

Product 2

HCID 13673470HCID 13673470, compoundHCID 86735026HCID 86735026, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 2'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid 3-chloro-4-methylbenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3-chloro-4-methylbenzyl ester of melting point 132° C (from ethanol).

Sources & evidence

ORD record
ord-feb2a9738d7a4e078699e1d68c3c0e31
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

Loading…