HCID 68121459, compound → HCID 13673470, compound

HRID 442182Notes

Reaction equation

HRID 442182 reaction equation
[C:1]([C:5]1[CH:35]=[CH:34][C:8]([CH2:9][O:10][C:11]([C:13]2[CH:14]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[N+:31]([O-:33])=[O:32])[C:15]([C:21]([O:23]C)=O)=C(C)[NH:17][C:18]=2[CH3:19])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)C>[CH3:9][O:10][C:11]([CH2:13][C:21](/[CH:15]=[CH:14]/[C:25]1[C:26]([N+:31]([O-:33])=[O:32])=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:23])=[O:12].[C:1]([C:5]1[CH:35]=[CH:34][C:8]([CH2:9][O:10][C:11](=[O:12])/[CH:13]=[C:18](\[NH2:17])/[CH3:19])=[CH:7][CH:6]=1)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 1

HCID 68121459HCID 68121459, compound

Product 2

HCID 13673470HCID 13673470, compoundHCID 86735027HCID 86735027, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 2'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid 4-tert.-butylbenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 4-tert.-butylbenzyl ester of melting point 146° C (from ethanol).

Sources & evidence

ORD record
ord-e1b6b2c6a4954aa5981a642b9c3c8cf7
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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