Ethanol → HCID 13673470, compound

HRID 442184Notes

Reaction equation

HRID 442184 reaction equation
[CH2:1]([O:8][C:9]([C:11]1[CH:12]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[N+:30]([O-:32])=[O:31])[C:13]([C:20]([O:22]C)=O)=[C:14](C)[N:15](C)[C:16]=1[CH3:17])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:33]([OH:35])C.CN(C)[CH:38]=[O:39].[CH2:41](O)C>>[CH3:33][O:35][C:38]([CH2:41][C:20](/[CH:13]=[CH:12]/[C:24]1[C:25]([N+:30]([O-:32])=[O:31])=[CH:26][CH:27]=[CH:28][CH:29]=1)=[O:22])=[O:39].[CH2:1]([O:8][C:9](=[O:10])/[CH:11]=[C:16](\[NH:15][CH3:14])/[CH3:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 19794673N,N-dimethylformamide ethanolHCID 54180260HCID 54180260, compound

Product 2

HCID 13673470HCID 13673470, compoundHCID 66660283HCID 66660283, compound

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 2'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-methylaminocrotonic acid benzyl ester in 120 ml of ethanol gave 1,2,6-trimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid benzyl ester of melting point 182° C (from ethanol/dimethylformamide).

Sources & evidence

ORD record
ord-4f4c65ea8b9240f5bbe703ee794c3bb4
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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