HCID 68121768, compound → HCID 70593900, compound

HRID 442187Notes

Reaction equation

HRID 442187 reaction equation
[F:1][C:2]([F:37])([F:36])[C:3]1[CH:35]=[CH:34][C:6]([CH2:7][O:8][C:9]([C:11]2C(C3C=CC=C([N+]([O-])=O)C=3)C(C(OC(C)C)=O)=C(C)[NH:15][C:16]=2[CH3:17])=[O:10])=[CH:5][CH:4]=1>C(O)C>[F:1][C:2]([F:36])([F:37])[C:3]1[CH:4]=[CH:5][C:6]([CH2:7][O:8][C:9](=[O:10])/[CH:11]=[C:16](\[NH2:15])/[CH3:17])=[CH:34][CH:35]=1

Participants

3

Reactant 1

HCID 68121768HCID 68121768, compound

Product 1

HCID 70593900HCID 70593900, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid isopropyl ester and 75 mmols of β-aminocrotonic acid 4-trifluoromethylbenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-isopropoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 4-trifluoromethylbenzyl ester of melting point 139° C (from ethanol).

Sources & evidence

ORD record
ord-d5ef532e37914a828633271344322d4c
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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