HCID 86735030, compound → HCID 86735029, compound

HRID 442190Notes

Reaction equation

HRID 442190 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:34]=[C:35]([O:39][CH3:40])[C:36]=1[O:37][CH3:38])[CH2:6][O:7][C:8]([C:10]1C(C2C=CC=C([N+]([O-])=O)C2=C=O)C(OCCOC)=C(C)[NH:14][C:15]=1[CH3:16])=[O:9]>C(O)C>[CH3:40][O:39][C:35]1[CH:34]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[C:36]=1[O:37][CH3:38])[CH2:6][O:7][C:8](=[O:9])/[CH:10]=[C:15](\[NH2:14])/[CH3:16]

Participants

3

Reactant 1

HCID 86735030HCID 86735030, compound

Product 1

HCID 86735029HCID 86735029, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid 2-methoxyethyl ester and 75 mmols of β-aminocrotonic acid 3,4,5-trimethoxybenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-(2-methoxyethoxy)-carbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 3,4,5-trimethoxybenzyl ester of melting point 160° C (from ethanol).

Sources & evidence

ORD record
ord-0b58a93e21fd415e847727b875dbc8e4
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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