HCID 67923826, compound → HCID 67724502, compound

HRID 442194Notes

Reaction equation

HRID 442194 reaction equation
[O:1]([CH2:8][CH2:9][O:10][C:11]([C:13]1C(C2C=CC=C([N+]([O-])=O)C=2)C(C(OC(C)C)=O)=C(C)[NH:17][C:18]=1[CH3:19])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C>[O:1]([CH2:8][CH2:9][O:10][C:11](=[O:12])/[CH:13]=[C:18](\[NH2:17])/[CH3:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 67923826HCID 67923826, compound

Product 1

HCID 67724502HCID 67724502, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 3'-nitrobenzylideneacetoacetic acid isopropyl ester and 75 mmols of β-aminocrotonic acid 2-phenoxyethyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-isopropoxycarbonyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid 2-phenoxyethyl ester of melting point 110° C (from ethanol).

Sources & evidence

ORD record
ord-db8c18c9bdbe483ab9b37042bf8d1e2b
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

Loading…