HCID 68121874, compound → HCID 13673470, compound

HRID 442196Notes

Reaction equation

HRID 442196 reaction equation
[CH3:1][CH:2]([O:10][C:11]([C:13]1[CH:14]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[N+:31]([O-:33])=[O:32])[C:15]([C:21]([O:23]C)=O)=C(C)[NH:17][C:18]=1[CH3:19])=[O:12])[C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][CH:4]=1>C(O)C>[CH3:2][O:10][C:11]([CH2:13][C:21](/[CH:15]=[CH:14]/[C:25]1[C:26]([N+:31]([O-:33])=[O:32])=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:23])=[O:12].[CH3:1][CH:2]([O:10][C:11](=[O:12])/[CH:13]=[C:18](\[NH2:17])/[CH3:19])[C:3]1[CH:4]=[CH:5][C:6]([Cl:9])=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 68121874HCID 68121874, compound

Product 2

HCID 13673470HCID 13673470, compoundHCID 86735023HCID 86735023, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Analogously to Example 1 heating a solution of 75 mmols of 2'-nitrobenzylideneacetoacetic acid methyl ester and 75 mmols of β-aminocrotonic acid α-methyl-4-chlorobenzyl ester in 120 ml of ethanol gave 2,6-dimethyl-3-methoxycarbonyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-5-carboxylic acid α-methyl-4-chlorobenzyl ester of melting point 206° C (from ethanol).

Sources & evidence

ORD record
ord-c0476045c1a54613abb05dc7d8927e31
Source dataset
uspto-grants-1977_08
Patent number
US04044141

Reaction notes

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