Ethylamine → HCID 178465192, compound

HRID 442235Notes

Reaction equation

HRID 442235 reaction equation
C[O:2][C:3](=O)[C@@H:4]([CH3:65])[NH:5][C:6](=[O:64])[C@H:7]([CH2:58][C:59]1[N:63]=[CH:62][NH:61][CH:60]=1)[NH:8][C:9](=[O:57])[C@H:10]([CH2:48][O:49][CH2:50][C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1)[NH:11][C:12](=[O:47])[C@H:13]([CH2:32][C:33]1[CH:38]=[CH:37][C:36]([O:39][CH2:40][C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)=[CH:35][CH:34]=1)[NH:14][C:15](=[O:31])[C@H:16]([CH2:25][C:26]1[N:30]=[CH:29][NH:28][CH:27]=1)[NH:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[CH2:67]([NH2:69])[CH3:68]>CO>[CH2:67]([NH:69][C:3](=[O:2])[C@@H:4]([CH3:65])[NH:5][C:6](=[O:64])[C@H:7]([CH2:58][C:59]1[N:63]=[CH:62][NH:61][CH:60]=1)[NH:8][C:9](=[O:57])[C@H:10]([CH2:48][O:49][CH2:50][C:51]1[CH:56]=[CH:55][CH:54]=[CH:53][CH:52]=1)[NH:11][C:12](=[O:47])[C@H:13]([CH2:32][C:33]1[CH:38]=[CH:37][C:36]([O:39][CH2:40][C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=2)=[CH:35][CH:34]=1)[NH:14][C:15](=[O:31])[C@H:16]([CH2:25][C:26]1[N:30]=[CH:29][NH:28][CH:27]=1)[NH:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:68]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 178501484HCID 178501484, compound

Product 1

HCID 178465192HCID 178465192, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Nα -Butoxycarbonyl-Nim -benzyl-L-histidyl-O-benzyl-L-tyrosyl-O-benzyl-L-seryl-L-histidyl-D-alanine methyl ester, 0.3 g., (Example 18) is treated with 200 ml. of methanol and 5 ml. of ethylamine at room temperature for three days. The above named product is isolated after evaporation of the solvent and the chromatographing of the residue on a silica gel column with ten percent methanol in benzene; 0.21 g.; m.p. 83°-88° C.

Workup

  1. addition, (Example 18) is treated with 200 ml
  2. customis isolated
  3. customafter evaporation of the solvent

Sources & evidence

ORD record
ord-701ef969489f4dcf93bc07a936592e0f
Source dataset
uspto-grants-1977_08
Patent number
US04043993

Reaction notes

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