Ammonia → HCID 53987572, compound

HRID 442238Notes

Reaction equation

HRID 442238 reaction equation
CO[C:3](=[O:69])[C@H:4]([CH2:60][O:61][CH2:62][C:63]1[CH:68]=[CH:67][CH:66]=[CH:65][CH:64]=1)[NH:5][C:6](=[O:59])[C@H:7]([CH2:44][C:45]1[CH:50]=[CH:49][C:48]([O:51][CH2:52][C:53]2[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=2)=[CH:47][CH:46]=1)[NH:8][C:9](=[O:43])[C@@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:15](=[O:42])[C@@H:16]1[CH2:20][CH2:19][CH2:18][N:17]1[C:21](=[O:41])[C@H:22]([CH2:31][C:32]1[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[NH:34][CH:33]=1)[NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25].[NH3:70]>CO>[C:27]([O:26][C:24]([NH:23][C@H:22]([C:21]([N:17]1[CH2:18][CH2:19][CH2:20][C@H:16]1[C:15]([N:11]1[CH2:12][CH2:13][CH2:14][C@H:10]1[C:9]([NH:8][C@H:7]([C:6]([NH:5][C@H:4]([C:3]([NH2:70])=[O:69])[CH2:60][O:61][CH2:62][C:63]1[CH:64]=[CH:65][CH:66]=[CH:67][CH:68]=1)=[O:59])[CH2:44][C:45]1[CH:50]=[CH:49][C:48]([O:51][CH2:52][C:53]2[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=2)=[CH:47][CH:46]=1)=[O:43])=[O:42])=[O:41])[CH2:31][C:32]1[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[NH:34][CH:33]=1)=[O:25])([CH3:29])([CH3:30])[CH3:28]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 54311645HCID 54311645, compound

Product 1

HCID 53987572HCID 53987572, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Nα -t-Butoxycarbonyl-L-tryptophyl-L-prolyl-L-prolyl-O-benzyl-L-tyrosyl-O-benzyl-L-serine methyl ester (0.5 g.) is dissolved in methanol, 25 ml., and the solution saturated with gaseous ammonia. The reaction is let stand for three days at room temperature, and the solvent then removed by evaporation.

Workup

  1. customthe solvent then removed by evaporation

Sources & evidence

ORD record
ord-9f837d222c314b2ba0b1135a9356c905
Source dataset
uspto-grants-1977_08
Patent number
US04043993

Reaction notes

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