反应详情

A few drops of bromine (from a total of 10.3 g., 0.064 mole) is added to N-(4-acetylphenyl)-N'-tert.-butylsulfamide (17.3 g., 0.064 mole) in dioxane (200 ml.) solution at 15° C. and the solution is stirred until the color is discharged. The remainder of the bromine is added during 5 min. and the solution is stirred for an additional 10 min. thereafter. The solution is concentrated in vacuo and the residue triturated with isopropyl ether to give 20.7 g. (92%) of intermediate, recrystallized from isopropanol, m.p. 160.5°-161° C. (dec.)

1. stirringthe solution is stirred for an additional 10 min.
2. concentrationThe solution is concentrated in vacuo
3. customthe residue triturated with isopropyl ether
4. customto give 20.7 g
5. custom(92%) of intermediate, recrystallized from isopropanol, m.p. 160.5°-161° C. (dec.)