HCID 21416949, compound → HCID 21416947, compound

HRID 442261Notes

Reaction equation

HRID 442261 reaction equation
[CH3:1]N(C)S(N[C:7]1[CH:12]=[CH:11][C:10]([CH:13](O)C(N)C)=[CH:9][CH:8]=1)(=O)=O.CN(C)[S:21](NC1C=CC(C(O)C(N)CC)=CC=1)(=[O:23])=[O:22].NC(C)C(C1C=CC(NS(N(C)C)(=O)=O)=CC=1)=[O:41].NC(CC)C(C1C=CC(NS(N(C)C)(=O)=O)=CC=1)=O.[OH:75][CH:76]([C:82]1[CH:87]=[CH:86][C:85]([NH:88][S:89]([NH:92][C:93]2[CH:98]=[CH:97][CH:96]=[CH:95][CH:94]=2)(=[O:91])=[O:90])=[CH:84][CH:83]=1)[CH2:77][NH:78][CH:79]([CH3:81])[CH3:80].C(N(C(C)C)CC(C1C=CC(NS(NC2C=CC=CC=2)(=O)=O)=CC=1)=O)C1C=CC=CC=1>>[C:10]1([CH3:13])[CH:9]=[CH:8][C:7]([S:21]([OH:23])(=[O:41])=[O:22])=[CH:12][CH:11]=1.[OH:75][CH:76]([C:82]1[CH:87]=[CH:86][C:85]([NH:88][S:89]([NH:92][C:93]2[CH:98]=[CH:97][C:96]([CH3:1])=[CH:95][CH:94]=2)(=[O:90])=[O:91])=[CH:84][CH:83]=1)[CH2:77][NH:78][CH:79]([CH3:81])[CH3:80]

Participants

7

Reactant 6

HCID 21416949HCID 21416949, compoundHCID 21416952HCID 21416952, compoundHCID 21416970HCID 21416970, compoundHCID 21416982HCID 21416982, compoundHCID 21416983HCID 21416983, compoundHCID 21416988HCID 21416988, compound

Product 1

HCID 21416947HCID 21416947, compound

Procedure

Procedure 8 is also applicable to the preparation of N,N-dimethyl-N'-[4-(1-hydroxy-2-aminopropyl)phenyl]sulfamide, and N,N-dimethyl-N'-[4-(1-hydroxy-2-aminobutyl)phenyl]sulfamide respectively from N-[4-(α-aminopropionyl)phenyl]-N',N'-dimethylsulfamide, and N-[4-(α-aminobutyryl)phenyl]-N',N'-dimethylsulfamide. Similarly, N-[4-(1-hydroxy-2-isopropylaminoethyl)phenyl]-N'-phenylsulfamide may be prepared from N-[4-(N-benzyl-N-isopropylglycyl)phenyl]-N'-phenylsulfamide.

Sources & evidence

ORD record
ord-d8411c68a2314c86961041ed9ca7f4dd
Source dataset
uspto-grants-1977_08
Patent number
US04044151

Reaction notes

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