HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4'-Fluoro-2'-methyl[1,1'-biphenyl]-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrogen iodide | HCID 24841 | — |
| Reactant | 4-Fluoro-4′-methoxy-2-methyl-1,1′-biphenyl | HCID 21416421 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4'-Fluoro-2'-methyl[1,1'-biphenyl]-4-ol | HCID 21416431 | — |
Reaction Steps
To a solution of 2.1 grams of 4-(2'-methyl-4'-fluorophenyl)-anisole in 50 ml. of boiling acetic acid is added 5 ml. of hydriodic acid and the boiling continued for 3 hours. Water is added and the reaction mixture cooled and the 4-(2'-methyl-4'-fluorophenyl)-phenol crystallizes. Further purification is then achieved by recrystallization of the solid from aqueous ethanol to yield 4-(2'-methyl-4'-fluorophenyl)-phenol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04044049 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-01fb65b25f014575859985c57f6e3c3e |
| Source note | uspto-grants-1977_08 |