HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 4'-Fluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl 4'-fluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylate | HCID 21416429 | — |
| Product | 4'-Fluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide | HCID 21416470 | — |
Reaction Steps
A mixture of 5.3 grams of methyl-2-hydroxy-5-(4'-fluorophenyl)-benzoate and 20 ml. of liquid ammonia is reacted in a bomb at 100° C. for 4 hours. After cooling the bomb is opened and the ammonia allowed to evaporate. The residue is then recrystallized from benzene to yield 2-hydroxy-5-(4'-fluorophenyl)-benzamide (m.p. 206° - 207° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04044049 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-82e3831daaf14367b10a16b9af5ae4c5 |
| Source note | uspto-grants-1977_08 |