反应详情

A mixture of 3.9 g. methyl-3-allyl-5-(4'-fluorophenyl)-salicylate, 40 ml. of methanol, and 10 ml. of 2.5 N sodium hydroxide solution is heated at reflux for 15 minutes. The mixture is concentrated in vacuo to remove methanol, diluted to 60 ml. with water, and acidified with dilute hydrochloric acid. The product is collected by filtration, dried, and recrystallized from benzene. The yield of 3-allyl-5-(4'-fluorophenyl)-2-hydroxy-benzoic acid is 3.4 g., m.p. 170° - 172° C.

1. additionA mixture of 3.9 g
2. temperatureat reflux for 15 minutes
3. concentrationThe mixture is concentrated in vacuo
4. customto remove methanol
5. additiondiluted to 60 ml
6. filtrationThe product is collected by filtration
7. customdried
8. customrecrystallized from benzene