Methyl Isocyanate → HCID 20486169, compound

Participants

Reaction Steps

5.6 g. (0.02 moles) of 7-nitro-5-phenyl-1,3,4,5-tetrahydro-2H-1,4-benzodiazepine-2-one are suspended in 25 ml. of dry ether, and 4.8 ml. (0.08 moles) of methyl isocyanate are added to the suspension. The reaction mixture is stirred at room temperature for 16 hours, thereafter the solid crystalline substance is filtered off and washed with ether. 6.03 g. (97.6%) of 4-methylcarbamoyl-5-phenyl-7-nitro-1,3,4,5-tetrahydro-2H-1,4-benzodiazepine-2-one are obtained, m.p.: 176°- 180° C. After recrystallization from ethanol, the product melts at 179°- 180° C. Rf2 = 0.4.

Provenance & Evidence