2-Propargylaminoacetaldehyde → 2-[1-Propargyl-3-(7-bromobenzothiazol-2-yl)ureido]acetaldehyde

HRID 442373Notes

Reaction equation

HRID 442373 reaction equation
[Br:1][C:2]1[C:10]2[S:9][C:8]([N:11]=[C:12]=[O:13])=[N:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH2:14]([NH:17][CH2:18][CH:19]=[O:20])[C:15]#[CH:16]>C1C=CC=CC=1>[CH2:14]([N:17]([CH2:18][CH:19]=[O:20])[C:12]([NH:11][C:8]1[S:9][C:10]2[C:2]([Br:1])=[CH:3][CH:4]=[CH:5][C:6]=2[N:7]=1)=[O:13])[C:15]#[CH:16]

Participants

4

Reactant 2

HCID 203927542-PropargylaminoacetaldehydeHCID 536464587-Bromobenzothiazol-2-yl isocyanate

Product 1

HCID 203571362-[1-Propargyl-3-(7-bromobenzothiazol-2-yl)ureido]acetaldehyde

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

7-Bromobenzothiazol-2-yl isocyanate dimer (0.1 mole), the dimethyl acetal of 2-propargylaminoacetaldehyde (0.2 mole) and benzene (100 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The reaction mixture is stirred at ambient temperatures for a period of about one hour. After this time the reaction mixture is filtered, and the filtrate is stripped of solvent to yield the desired product the dimethyl acetal of 2-[1-propargyl-3-(7-bromobenzothiazol-2-yl)ureido]acetaldehyde as the residue.

Workup

  1. customequipped with a mechanical stirrer
  2. filtrationAfter this time the reaction mixture is filtered

Sources & evidence

ORD record
ord-784815c8571e4b9fb65410d0954150d5
Source dataset
uspto-grants-1977_08
Patent number
US04045446

Reaction notes

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