HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-Chloro-2-(methylsulfanyl)-1-benzofuran-3(2H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-(5-Chloro-2-hydroxyphenyl)-2-(methanesulfinyl)ethan-1-one | HCID 21828250 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 5-Chloro-2-(methylsulfanyl)-1-benzofuran-3(2H)-one | HCID 21414520 | — |
Reaction Steps
5-Chloro-2-hydroxy-1-[(methylsulfinyl)acetyl]benzene (6.0 g) and trifluoroacetic acid (6 g) are refluxed in benzene (50 ml) for one hour under nitrogen. The solvent is removed under reduced pressure to give a yellow oil, which crystallizes on standing. Recrystallization from ethanol gives white crystals. (3.0 g 54%) m.p. 76°-78° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04045451 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-0bb14570eb4e4679bcda3b20f4c8d1d9 |
| Source note | uspto-grants-1977_08 |