Phosphorus oxide (P4O10) → HCID 21414406, compound

Participants

Reaction Steps

The general procedures of Example 1 are repeated. From 2-amino-4-chloro-N-methyldiphenylamine and 1-ethylisonipecotoyl chloride, 5'-chloro-1-ethyl-2'-(N-methylanilino)-isonipecotanilide is prepared. This intermediate is cyclized by heating with a mixture of phosphorus oxychloride and phosphorus pentoxide and, after isolation and purification by the methods described in Examples 1 and 2, 8-chloro-11-(1-ethyl-4-piperidyl)-5-methyl-5H-dibenzo[b,e][1,4]diazepine is obtained.

Provenance & Evidence