HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → (R)-(+)-3,7-dimethyloctanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Ethyl (3R)-3,7-dimethyloctanoate | HCID 13191832 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | (R)-(+)-3,7-dimethyloctanoic acid | HCID 13191833 | 60% |
Reaction Steps
Hydrolysis: 400 mg. (2 mmol) of 3(R),7-dimethyl octanoic acid ethyl ester was refluxed in 6 N NaOH (1 ml.) and methanol (4 ml.) for 2 hours. It was worked up as in Example 10 to give 207 mg. (60% yield) of 3(R),7-dimethyl octanoic acid (R-(+)-dihydrocitronellic acid), [α]D25 + 6.81° (c=5.039, CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04045475 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-e3a44969ee5e443b9f7ff047a3c13f26 |
| Source note | uspto-grants-1977_08 |