2-Chloro-N-(2,6-dimethylphenyl)acetamide → HCID 54386024, compound

HRID 442480Notes

Reaction equation

HRID 442480 reaction equation
Cl.Cl.[NH2:3][CH:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][C:13]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:14])[CH2:6][CH2:5]1.[CH3:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[C:23]=1[NH:29][C:30](=[O:33])[CH2:31]Cl>>[CH3:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH3:28])[C:23]=1[NH:29][C:30]([CH2:31][NH:3][CH:4]1[CH2:9][CH2:8][N:7]([CH2:10][CH2:11][CH2:12][C:13]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[O:14])[CH2:6][CH2:5]1)=[O:33]

Participants

3

Reactant 2

HCID 707982-Chloro-N-(2,6-dimethylphenyl)acetamideHCID 227548374-Amino-1-(4-phenyl-4-oxobutyl)piperidine dihydrochloride

Product 1

HCID 54386024HCID 54386024, compound

Procedure

4-Amino-1-(4-phenyl-4-oxobutyl) piperidine dihydrochloride (1.75g) was condensed with N-(2,6-dimethylphenyl) chloroacetamide (0.999) in the manner of Example 1 to give the title compound which was converted to the hydrochloride salt (1.85g), m.p. 276.8° Analysis: Found, C, 62.26; H, 7.48; N, 8.68; C25H33N3O2. 2HC1 requires C, 62.25; H, 7.34; N, 8.75%

Sources & evidence

ORD record
ord-a0428623ee5a4850bb6e2442d296054a
Source dataset
uspto-grants-1977_08
Patent number
US04045566

Reaction notes

Loading…