2-Chloro-N-cyclohexylacetamide → 2-[1-(3-Benzoylpropyl)-4-piperidinylamino]-N-cyclohexylacetamide

HRID 442485Notes

Reaction equation

HRID 442485 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][CH2:9][CH2:10][C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])[CH2:4][CH2:3]1.[CH:19]1([NH:25][C:26](=[O:29])[CH2:27]Cl)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[C:11]([CH2:10][CH2:9][CH2:8][N:5]1[CH2:6][CH2:7][CH:2]([NH:1][CH2:27][C:26]([NH:25][CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)=[O:29])[CH2:3][CH2:4]1)(=[O:12])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

3

Reactant 2

HCID 2223652-Chloro-N-cyclohexylacetamideHCID 126085374-Amino-1-(4-phenyl-4-oxobutyl)piperidine

Product 1

HCID 538468502-[1-(3-Benzoylpropyl)-4-piperidinylamino]-N-cyclohexylacetamide

Procedure

Using a procedure analogous to Example 1 4-amino-1-(4-phenyl-4-oxobutyl) piperidine may be reacted with N-cyclohexylchloracetamide to give the title compound.

Sources & evidence

ORD record
ord-adcd38764eb343009434d459e62441c7
Source dataset
uspto-grants-1977_08
Patent number
US04045566

Reaction notes

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