反应详情

14.2 g (0.1 mol) of 2-methoxy-4,6-dihydroxy-pyrimidine are added while stirring to 50 cc of sodium hydroxide solution 2N and the mixture is stirred for half an hour with heating to 50°. 17.0 g (0.11 mol) of diethyl sulphate are subsequently added dropwise over the course of 20 minutes and with stirring; by adding sodium hydroxide solution 2N the pH value should, if possible, be kept at between 8 and 8.2. The mixture is then stirred at 50°, sodium hydroxide solution 2N is added from time to time until the pH remains constant (approximately 3 hours). The reaction mixture is subsequently cooled to 0°, the precipitate is suction filtered and washed with a small quantity of ethanol. After drying in a high vacuum at 80°, the substance has a M.P. of 192°-194°.

1. temperaturewith heating to 50°
2. stirringwith stirring
3. stirringThe mixture is then stirred at 50°
4. custom(approximately 3 hours)
5. temperatureThe reaction mixture is subsequently cooled to 0°
6. filtrationfiltered
7. washwashed with a small quantity of ethanol
8. customAfter drying in a high vacuum at 80°