HCID 178418361, compound → HCID 178479558, compound

Participants

Reaction Steps

100 mg of 5% palladium on charcoal in 15 ml of glacial acetic acid are pretreated with hydrogen. Then a solution of 850 mg of 5-chloro-orotyl-L-histidyl-L-prolinamide in 30 ml of glacial acetic acid are added and the mixture is shaken in a hydrogen atmosphere at normal pressure and at room temperature. After consumption of 2 m moles of hydrogen the catalyst is filtered off, the filtrate evaporated to a small volume and treated with absolute ether. The precipitate is separated, washed with ether and dried to give orotyl-L-histidyl-L-prolinamide-hydrochloride in almost quantitative yield.

Provenance & Evidence