Imidazole → 2,4-Dichloro-beta-(1-imidazolyl)propiophenone

Participants

Reaction Steps

7.0 g. of 2,4-dichlorophenyl vinyl ketone (prepared by Jones oxidation of 2,4-dichlorophenyl vinyl carbinol using the general method described in J. Chem. Soc. (C), 1966, p. 1972) in 350 ml. of anhydrous ether was treated with 3.5 g. of imidazole, the solution stirred overnight and then washed with water (3 × 30 ml.). The solution is dried (MgSO4) and evaporated to give 2,4-dichloro-β-(1-imidazolyl)propiophenone as an amber gum (8.65 g.). The hydrochloride salt may be precipitated from ether and recrystallized from methanol/acetone as colorless rods, m.p. 105.5°-110° C.

Provenance & Evidence