Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

A solution of 9-(4-benzyl-2-morpholinylmethyl)-9,10-dihydro-9,10-ethanoanthracene (150 mg) in acetic acid was added to 10% palladium on charcoal (60 mg) pretreated under hydrogen in hydrochloric acid, and the resulting mixture was stirred under hydrogen at room temperature for 14 hours. After elimination of the catalyst by filtration, the filtrate was evaporated. The residue was neutralized with 10% aqueous sodium hydroxide solution and extracted with chloroform. The chloroform extract was washed with water, dried over anhydrous sodium sulfate and evaporated to dryness. The residue was purified over silica gel chromatography to give 9-(2-morpholinylmethyl)-9,10-dihydro-9,10-ethanoanthracene, M.P. 242° - 244° C. (hydrochloride).

Provenance & Evidence