反应详情

A mixture of 2.6 g. of (2-amino-3-benzoylphenyl)acetic acid and sodium hydroxide (0.1 mole) in 25 ml. of water was stirred for approximately 10 min. and then heated to reflux under nitrogen. The reaction mixture was then cooled and filtered. The filtrate was evaporated down to approximately 2 ml., refiltered and a large volume of acetone added to the filtrate to precipitate the product as bright yellow flakes. Yield 70%.

1. additionA mixture of 2.6 g
2. temperatureheated
3. temperatureto reflux under nitrogen
4. temperatureThe reaction mixture was then cooled
5. filtrationfiltered
6. customThe filtrate was evaporated down to approximately 2 ml
7. additiona large volume of acetone added to the filtrate
8. customto precipitate the product as bright yellow flakes