Amfenac → Magnesium;bis(2-(2-amino-3-benzoylphenyl)acetate);trihydrate

HRID 442556Notes

Reaction equation

HRID 442556 reaction equation
[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([OH:19])=[O:18].[Cl-].[Mg+2:21].[Cl-]>>[OH2:15].[OH2:15].[OH2:15].[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([O-:19])=[O:18].[Mg+2:21].[NH2:1][C:2]1[C:7]([C:8](=[O:15])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:16][C:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 2136AmfenacHCID 5360315Magnesium Chloride

Product 1

HCID 12901240Magnesium;bis(2-(2-amino-3-benzoylphenyl)acetate);trihydrate

Procedure

An aqueous solution of 6.36 g. (0.02 mole) of 2-amino-3-benzoylphenylacetic acid was treated with an aqueous solution of magnesium chloride (0.01 mole). A precipitate formed immediately. After 15 min. of stirring, the bright yellow precipitate was filtered and dried. The yield was 4.06 g. and the salt melted over the broad range of 150°-190° C.

Workup

  1. customA precipitate formed immediately
  2. filtrationthe bright yellow precipitate was filtered
  3. customdried
  4. custommelted over the broad range of 150°-190° C.

Sources & evidence

ORD record
ord-6a4ecb94a8394a0da0b8ce856cab6bc4
Source dataset
uspto-grants-1977_08
Patent number
US04045576

Reaction notes

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