反应详情

温度

125 °C

5-Bromo4chloro-7(2-hydroxyethoxymethyl)pyrrolo[2,3-d]pyrimidine (8b, 0.75) was dissolved in dry methanol (10 mL) and methanol saturated with ammonia (40 mL) was then added to this solution. The reaction mixture was heated at 125° C. in a sealed reaction vessel for 10 hours The solvent was removed at 40° C. under reduced pressure and the resulting solid was then subjected to column chromatography. Elution of the silica get column (20×3 cm) with 5% MeOH in CHCl3 yielded a solid after evaporation of the appropriate UV absorbing fractions.

1. customwas removed at 40° C. under reduced pressure
2. washElution of the silica
3. customget column (20×3 cm) with 5% MeOH in CHCl3
4. customyielded a solid
5. customafter evaporation of the appropriate UV
6. customabsorbing fractions